Volume : 7, Issue : 12, December - 2018

Sodium valproate induced cataract: A case report

Prof. Mohammad Nasiruddin, Dr. Irfan Ahmad Khan, Prof. Mohammad Ashraf

Abstract :

<p>&nbsp;<span style="font-size:12.0pt;line-height:115%;&#10;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;mso-fareast-font-family:&quot;Times New Roman&quot;;&#10;mso-fareast-theme-font:minor-fareast;mso-ansi-language:EN-US;mso-fareast-language:&#10;EN-US;mso-bidi-language:AR-SA">Valproic acid (VPA) is used for the treatment of epileptic seizures. Here we report, a case of cataract following sodium valproate administration for treatment of epileptic seizures. A 25 year female patient presented to ophthalmology out</span><span style="font-size:12.0pt;&#10;line-height:115%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;mso-fareast-font-family:&#10;&quot;MS Gothic&quot;;mso-ansi-language:EN-US;mso-fareast-language:EN-US;mso-bidi-language:&#10;AR-SA">-</span><span style="font-size:12.0pt;line-height:115%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;mso-fareast-font-family:&quot;Times New Roman&quot;;mso-fareast-theme-font:minor-fareast;&#10;mso-ansi-language:EN-US;mso-fareast-language:EN-US;mso-bidi-language:AR-SA">patient department (OPD) with complaints of </span><span style="font-size:12.0pt;&#10;line-height:115%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;mso-fareast-font-family:&#10;&quot;Times New Roman&quot;;mso-ansi-language:EN-US;mso-fareast-language:EN-US;&#10;mso-bidi-language:AR-SA">poor vision in both eyes</span><span style="font-size:&#10;12.0pt;line-height:115%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;mso-fareast-font-family:&#10;&quot;Times New Roman&quot;;mso-fareast-theme-font:minor-fareast;mso-ansi-language:EN-US;&#10;mso-fareast-language:EN-US;mso-bidi-language:AR-SA">. She was diagnosed as a patient of bilateral</span><span style="font-size:12.0pt;line-height:115%;&#10;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;mso-fareast-font-family:&quot;Times New Roman&quot;;&#10;mso-ansi-language:EN-US;mso-fareast-language:EN-US;mso-bidi-language:AR-SA"> subcapsular cataract. </span><span style="font-size:12.0pt;line-height:115%;&#10;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;mso-fareast-font-family:&quot;Times New Roman&quot;;&#10;mso-fareast-theme-font:minor-fareast;mso-ansi-language:EN-US;mso-fareast-language:&#10;EN-US;mso-bidi-language:AR-SA">She was on sodium valproate therapy for treatment of epileptic seizures for past 6 years. According to the Naranjo&rsquo;s scale, the effect of sodium valproate in our patient was scored 6 indicating a probable likelihood of causing cataract. It was a probable cause of cataract according to World Health Organization (WHO) causality scale. </span><span style="font-size:12.0pt;mso-bidi-font-size:16.0pt;line-height:115%;font-family:&#10;&quot;Times New Roman&quot;,&quot;serif&quot;;mso-fareast-font-family:&quot;Times New Roman&quot;;mso-fareast-theme-font:&#10;minor-fareast;mso-ansi-language:EN-US;mso-fareast-language:EN-US;mso-bidi-language:&#10;AR-SA">She underwent surgical treatment for cataract</span></p>