Volume : 7, Issue : 12, December - 2018

A study of serum amylase levels in Acute Organophosphorous Poisoning at Tertiary care Hospital.

Dr. Viney Sambyal, Dr. Shahbaz Khan

Abstract :

<p>&nbsp;</p> <p class="MsoNormal"><span lang="EN-IN" style="font-size:14.0pt;line-height:115%">Introduction: In India, OP compounds cause more self-poisoning deaths in southern and central India. In Northern India, aluminum phosphide causes most deaths with a fatality ratio. Poisoning due to occupational exposure, accounted for about one fifth of the incidents, with a fatality ratio of less than 1%. More than 90% of the non-occupational incidents were suicidal, with a fatality rate more than 10% and the majority of the subjects are young males. Accidental exposures accounted for 8-10% of the incidents and homicidal use (less than 1%) were other forms of poisoning. The reported overall mortality following OP insecticide poisoning varies from 4-30% in different countries and institutions. <o:p></o:p></span></p> <p class="MsoNormal"><span lang="EN-IN" style="font-size:14.0pt;line-height:115%">Aim: To estimate serum Amylase levels in acute organophosphorus compound poisoning and the find out the clinical outcomes.<o:p></o:p></span></p> <p class="MsoNormal"><span lang="EN-IN" style="font-size:14.0pt;line-height:115%"><span style="mso-spacerun:yes">&nbsp;</span>Materials and Methods: The study was conducted in Government Medical College and Hospital, Jammu. Study duration was from January 2018 to OCT.2018. Of a total of 350 patients with organophosphorus compound poisoning admitted to the hospital during the study period, 150 were included in the study. 50 healthy (age matched) individuals were kept as a control. Biochemical evaluation which includes Serum Amylase, Blood glucose, urea, creatinine, and Liver function tests were analyzed and matched among the two groups. Results: The biochemical results have not shown much variation from the normal levels in our study.<o:p></o:p></span></p> <p class="MsoNormal"><span lang="EN-IN" style="font-size:14.0pt;line-height:115%">In the study, the Amylase levels were significantly elevated at the time of admission (185.2 U/L) and have shown a gradual remission with proper treatment. The mean Amylase level in severely poisoned patients was 297.7 U/L which was significantly (P &lt; 0.01) higher than the healthy control group. On comparing the Amylase levels in first 24 hours against control, the variations were considered to be significant (P &lt; 0.01).<o:p></o:p></span></p> <p class="MsoNormal"><span lang="EN-IN" style="font-size:14.0pt;line-height:115%"><span style="mso-spacerun:yes">&nbsp;</span>Conclusion: From the observation we made, it could be suggested that OP pesticide poisoning is a serious condition that needs rapid diagnosis and treatment. The mean Amylase level in first 24 hours of OP poisoning was 154 U/L which is significantly higher than the control groups.<o:p></o:p></span></p>