Volume : 7, Issue : 12, December - 2018

THE EFFECT OF PREOPERATIVE PREGABALIN ON ATTENUATION OF HEMODYNAMIC RESPONSES TO LARYNGOSCOPY & ENDOTRACHEAL INTUBATION

Dr. Ankit Jain, Dr. Abhishek Gupta

Abstract :

<p>&nbsp;</p> <p class="MsoNormal" style="text-align:justify;line-height:200%"><b style="mso-bidi-font-weight:normal"><span style="font-size:14.0pt;line-height:&#10;200%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">Introduction:</span></b><span style="font-size:14.0pt;line-height:200%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"> This study was designed to evaluate the effect of preoperative pregabalin premedication on attenuation of hemodynamic responses to laryngoscopy and endotracheal intubation.<o:p></o:p></span></p> <p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;text-align:&#10;justify;line-height:200%"><b style="mso-bidi-font-weight:normal"><span style="font-size:14.0pt;line-height:200%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">Material and methods:</span></b><span style="font-size:14.0pt;line-height:200%;&#10;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"><span style="mso-spacerun:yes">&nbsp; </span>Eighty patients of either sex , belonging to American Society of Anesthesiologists grade 1 and 2 , undergoing elective surgeries under general anesthesia with endotracheal intubation , were randomly assigned to one of<span style="mso-spacerun:yes">&nbsp; </span>the two groups of forty patients each , in a double blinded manner. Group P received pregabalin 150 mg and Group C received placebo orally, one hour prior to induction . The preoperative level of sedation was assessed by the Ramsay sedation scale in the operating room , before induction .&nbsp; Heart rate , systolic blood pressure (SBP) , diastolic blood pressure (DBP) and mean arterial blood pressure (MAP) <span style="mso-spacerun:yes">&nbsp;</span>were<span style="mso-spacerun:yes">&nbsp; </span>monitored<span style="mso-spacerun:yes">&nbsp; </span>and recorded as - before and after induction ,immediately after intubation and 1, 3 , 5 minutes after intubation ; thereafter at every 5 minute intervals till end of surgery and also every 15 minutes for 4 hours postoperatively .<o:p></o:p></span></p> <p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;text-align:&#10;justify;line-height:200%"><b style="mso-bidi-font-weight:normal"><span style="font-size:14.0pt;line-height:200%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">Results:</span></b><span style="font-size:14.0pt;line-height:200%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"> Patients in Group P had lower heart rate , SBP, DBP and MAP at all time points <span style="mso-spacerun:yes">&nbsp;</span>suggesting greater hemodynamic stability and better attenuation of the hemodynamic response , when compared with Group C.<o:p></o:p></span></p> <p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;text-align:&#10;justify;line-height:200%"><b style="mso-bidi-font-weight:normal"><span style="font-size:14.0pt;line-height:200%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">Conclusion:</span></b><span style="font-size:14.0pt;line-height:200%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"> Oral pregabalin 150 mg may be accepted as an effective premedication to attenuate hemodynamic responses to laryngoscopy and intubation.<o:p></o:p></span></p>