Volume : 7, Issue : 11, November - 2018

Efficacy of Neutrophil gelatinase associated lipocalin as an early marker of AKI in adult ICU patients

Dr. Rudach Mitul Devanand, Dr. V. Padma

Abstract :

<p>&nbsp;<span lang="EN-IN" style="font-size: 12pt; line-height: 115%; border: 1pt none windowtext; padding: 0in;">Early diagnosis of AKI currently depends on detection of reduced kidney function by the rise in serum creatinine concentration, which is a delayed and unreliable measure in the acute setting. <span style="color:#231F20">The lack of specific biomarkers for early recognition of AKI has meant a delayed onset of treatment. </span></span><span lang="EN-IN" style="border: 1pt none windowtext; padding: 0in;">NGAL fulfils many of the characteristics important for a useful AKI biomarker. NGAL represents a significant component in the pathophysiology of the disease. The concentration of NGAL in urine or plasma rises rapidly in a dose-dependent manner that is proportional to the degree of damage. <b>Aims and objectives </b></span><span lang="EN-IN" style="font-size: 12pt; line-height: 115%; border: 1pt none windowtext; padding: 0in;">Assessing efficacy of NGAL as a marker of early development of acute kidney injury in adult ICU patients and compare among AKI and NON-AKI patients.</span>< /> <b><span lang="EN-IN" style="font-size:12.0pt;&#10;line-height:115%;font-family:&quot;Calii&quot;,&quot;sans-serif&quot;;mso-ascii-theme-font:minor-latin;&#10;mso-fareast-font-family:Calii;mso-fareast-theme-font:minor-latin;mso-hansi-theme-font:&#10;minor-latin;mso-bidi-font-family:&quot;Times New Roman&quot;;mso-bidi-theme-font:minor-bidi;&#10;border:none windowtext 1.0pt;mso-border-alt:none windowtext 0in;padding:0in;&#10;mso-ansi-language:EN-IN;mso-fareast-language:EN-US;mso-bidi-language:AR-SA">Method </span></b><span lang="EN-IN" style="font-size:12.0pt;line-height:115%;&#10;font-family:&quot;Calii&quot;,&quot;sans-serif&quot;;mso-ascii-theme-font:minor-latin;mso-fareast-font-family:&#10;Calii;mso-fareast-theme-font:minor-latin;mso-hansi-theme-font:minor-latin;&#10;mso-bidi-font-family:&quot;Times New Roman&quot;;mso-bidi-theme-font:minor-bidi;&#10;border:none windowtext 1.0pt;mso-border-alt:none windowtext 0in;padding:0in;&#10;mso-ansi-language:EN-IN;mso-fareast-language:EN-US;mso-bidi-language:AR-SA">It is a hospital based prospective study of 53 patients, which is conducted at SREE BALAJI MEDICAL COLLEGE CHENNAI. The material for study is formed by adult patients admitted to adult ICU. Between DECEMBER 2016 </span><span style="font-size:12.0pt;line-height:115%;font-family:&quot;Calii&quot;,&quot;sans-serif&quot;;&#10;mso-ascii-theme-font:minor-latin;mso-fareast-font-family:Calii;mso-fareast-theme-font:&#10;minor-latin;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:&quot;Times New Roman&quot;;&#10;mso-bidi-theme-font:minor-bidi;border:none windowtext 1.0pt;mso-border-alt:&#10;none windowtext 0in;padding:0in;mso-ansi-language:EN-IN;mso-fareast-language:&#10;EN-US;mso-bidi-language:AR-SA">&ndash;<span lang="EN-IN"> AUGUST 2018 fulfilling the inclusion and exclusion criteria. <b>Conclusion </b>Our study demonstrated that admission blood NGAL measurements are useful in early diagnosis of AKI.</span></span></p>