Volume : 7, Issue : 11, November - 2018

ASSOCIATION BETWEEN THE EXPRESSION OF MATRIX METALLO PROTEINASE-2 AND COLLAGEN TYPE-III THICKNESS IN FASCIA ENDOPELVIC OF MENOPAUSAL WOMEN WITH PELVIC ORGAN PROLAPSE

M. Rhiza Z. Tala

Abstract :

<p>&nbsp;<span lang="IN" style="font-size:12.0pt;line-height:&#10;107%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;mso-fareast-font-family:Calii;&#10;mso-fareast-theme-font:minor-latin;mso-ansi-language:IN;mso-fareast-language:&#10;EN-US;mso-bidi-language:AR-SA">Pelvic organ prolapse (POP) is a disturbing conditions </span><span style="font-size:12.0pt;line-height:107%;font-family:&#10;&quot;Times New Roman&quot;,&quot;serif&quot;;mso-fareast-font-family:Calii;mso-fareast-theme-font:&#10;minor-latin;mso-ansi-language:EN-US;mso-fareast-language:EN-US;mso-bidi-language:&#10;AR-SA">in</span><span lang="IN" style="font-size:12.0pt;line-height:107%;&#10;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;mso-fareast-font-family:Calii;&#10;mso-fareast-theme-font:minor-latin;mso-ansi-language:IN;mso-fareast-language:&#10;EN-US;mso-bidi-language:AR-SA"> menopausal women. MMP-2 </span><span style="font-size:12.0pt;line-height:107%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;mso-fareast-font-family:Calii;mso-fareast-theme-font:minor-latin;mso-ansi-language:&#10;EN-US;mso-fareast-language:EN-US;mso-bidi-language:AR-SA">eak </span><span lang="IN" style="font-size:12.0pt;line-height:107%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;mso-fareast-font-family:Calii;mso-fareast-theme-font:minor-latin;mso-ansi-language:&#10;IN;mso-fareast-language:EN-US;mso-bidi-language:AR-SA">collagen type-III in endopelvic fascia. This study investigate the association between the expression of MMP-2 and collagen type-III thickness in endopelvic fascia of menopausal women with POP. This was a case-control study involved menopausal women who visited Urogynecology unit of Department of Obstetric and Gynecology, Adam Malik General Hospital from July 2017 to the date </span><span style="font-size:12.0pt;line-height:&#10;107%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;mso-fareast-font-family:Calii;&#10;mso-fareast-theme-font:minor-latin;mso-ansi-language:EN-US;mso-fareast-language:&#10;EN-US;mso-bidi-language:AR-SA">un</span><span lang="IN" style="font-size:12.0pt;&#10;line-height:107%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;mso-fareast-font-family:&#10;Calii;mso-fareast-theme-font:minor-latin;mso-ansi-language:IN;mso-fareast-language:&#10;EN-US;mso-bidi-language:AR-SA">til the number of minimal sample was achieved. MMP-2 level and collagen type-III thickness were measured from biopsy speciment taken during hysterectomy and blood serum. 45 menopausal women with POP as case group and 47 menopausal women without POP as control group. </span><span style="font-size:12.0pt;line-height:107%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;mso-fareast-font-family:Calii;mso-fareast-theme-font:minor-latin;mso-ansi-language:&#10;EN-US;mso-fareast-language:EN-US;mso-bidi-language:AR-SA">N</span><span lang="IN" style="font-size:12.0pt;line-height:107%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;mso-fareast-font-family:Calii;mso-fareast-theme-font:minor-latin;mso-ansi-language:&#10;IN;mso-fareast-language:EN-US;mso-bidi-language:AR-SA">egative correlation between the expression of MMP-2 and collagen type-III thickness with r value = 0,638 (close to 0). This study found that higher expression of MMP-2 was associated with lower collagen type-III thickness in fascia endopelvic of menopausal women</span></p>