Volume : 7, Issue : 9, September - 2018

Comparison of serum lipid levels between suicidal and non-suicidal Depression patients

S. P. Baral, V. S. Pal, P. Rastogi

Abstract :

<p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;text-align:&#10;justify"><b style="mso-bidi-font-weight:normal"><span lang="EN-IN" style="font-size:10.0pt;line-height:115%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;color:black;mso-themecolor:text1;mso-ansi-language:EN-IN">Background:<o:p></o:p></span></b></p> <p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;text-align:&#10;justify"><span lang="EN-IN" style="font-size:10.0pt;line-height:115%;font-family:&#10;&quot;Times New Roman&quot;,&quot;serif&quot;;color:black;mso-themecolor:text1;mso-ansi-language:&#10;EN-IN">Lower levels of circulating lipids is risk factor for suicide in depressive disorder. </span><span lang="EN-IN" style="font-size:10.0pt;&#10;line-height:115%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;mso-ansi-language:EN-IN;&#10;mso-bidi-font-weight:bold">A reduced serum cholesterol level may be accompanied by changes in viscosity and function of serotonin receptors and transporter, thus predisposing to suicidal behaviour.<o:p></o:p></span></p> <p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;text-align:&#10;justify"><b style="mso-bidi-font-weight:normal"><span lang="EN-IN" style="font-size:10.0pt;line-height:115%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;color:black;mso-themecolor:text1;mso-ansi-language:EN-IN">Materials and Methods:<o:p></o:p></span></b></p> <p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;text-align:&#10;justify"><span lang="EN-IN" style="font-size:10.0pt;line-height:115%;font-family:&#10;&quot;Times New Roman&quot;,&quot;serif&quot;;color:black;mso-themecolor:text1;mso-ansi-language:&#10;EN-IN">A total of 100 depressive patients (50 suicidal and non-suicidal) and 100 healthy matched control subjects were recruited from mental hospital, Indore and lipid profile was measured.<o:p></o:p></span></p> <p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;text-align:&#10;justify"><b style="mso-bidi-font-weight:normal"><span lang="EN-IN" style="font-size:10.0pt;line-height:115%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;color:black;mso-themecolor:text1;mso-ansi-language:EN-IN">Results:<o:p></o:p></span></b></p> <p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;text-align:&#10;justify"><span lang="EN-IN" style="font-size:10.0pt;line-height:115%;font-family:&#10;&quot;Times New Roman&quot;,&quot;serif&quot;;color:black;mso-themecolor:text1;mso-ansi-language:&#10;EN-IN">Suicidal depression patient group has shown significantly less Total Cholesterol, Triglyceride, LDL-c, VLDL-c than Non-Suicidal depression patient group<b style="mso-bidi-font-weight:normal"><o:p></o:p></b></span></p> <p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;text-align:&#10;justify"><b style="mso-bidi-font-weight:normal"><span lang="EN-IN" style="font-size:10.0pt;line-height:115%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;color:black;mso-themecolor:text1;mso-ansi-language:EN-IN">Conclusion:<o:p></o:p></span></b></p> <p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;text-align:&#10;justify"><span lang="EN-IN" style="font-size:10.0pt;line-height:115%;font-family:&#10;&quot;Times New Roman&quot;,&quot;serif&quot;;color:black;mso-themecolor:text1;mso-ansi-language:&#10;EN-IN">Lower levels of serum cholesterol is predictor of suicidal behaviour in depressive disorder.<b style="mso-bidi-font-weight:normal"><o:p></o:p></b></span></p>