Volume : 7, Issue : 8, August - 2018

STATUS OF SERUM CALCIUM AND VITAMIN-D LEVEL IN HYPOTHYROIDISM IN ONE OF THE RURAL AREA OF CENTRAL MAHARASHTRA

Yogita Dubey, Archana Dhok, Ruchir Khare

Abstract :

<p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;text-align:&#10;justify;line-height:normal"><b><span style="font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">Introduction:</span></b><span style="font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"> Thyroid gland disorders are very common among endocrine diseases and incidence and prevalence increase with age but also affect younger age group. Thyroid disorders have direct and indirect effect on mineral metabolism.</span><span style="font-size:12.0pt;font-family:&#10;&quot;Times New Roman&quot;,&quot;serif&quot;"> Peoples from rural area have lack of knowledge and awareness regarding thyroid disorders and its impact on calcium and Vitamin D status.<o:p></o:p></span></p> <p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;text-align:&#10;justify;line-height:normal"><b><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">Aim &amp; objectives: </span></b><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">To<span style="mso-spacerun:yes">&nbsp; </span>evaluate<span style="mso-spacerun:yes">&nbsp; </span>status of serum Calcium and Vitamin D level<span style="mso-spacerun:yes">&nbsp; </span>in patients of hypothyroidism<span style="mso-spacerun:yes">&nbsp; </span>according to<span style="mso-spacerun:yes">&nbsp; </span>age<span style="mso-spacerun:yes">&nbsp; </span>and<span style="mso-spacerun:yes">&nbsp; </span>gender<span style="mso-spacerun:yes">&nbsp; </span>in<span style="mso-spacerun:yes">&nbsp; </span>rural<span style="mso-spacerun:yes">&nbsp; </span>area.<o:p></o:p></span></p> <p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;text-align:&#10;justify;line-height:normal;mso-layout-grid-align:none;text-autospace:none"><b><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">Material &amp; methods:</span></b><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"> This<span style="mso-spacerun:yes">&nbsp; </span>prospective<span style="mso-spacerun:yes">&nbsp; </span>case<span style="mso-spacerun:yes">&nbsp; </span>control<span style="mso-spacerun:yes">&nbsp; </span>study<span style="mso-spacerun:yes">&nbsp; </span>was conducted<span style="mso-spacerun:yes">&nbsp; </span>in<span style="mso-spacerun:yes">&nbsp; </span>Department<span style="mso-spacerun:yes">&nbsp; </span>of Biochemistry,<span style="mso-spacerun:yes">&nbsp; </span>JNMC,<span style="mso-spacerun:yes">&nbsp; </span>Sawangi,<span style="mso-spacerun:yes">&nbsp; </span>Wardha<span style="mso-spacerun:yes">&nbsp; </span></span><span style="font-size:12.0pt;&#10;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;mso-fareast-font-family:Calii">in patients of hypothyroidism after obtaining i</span><span style="font-size:12.0pt;&#10;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">nformed consent.Study group comprises of 100 subjects. 50 cases of hypothyroidism of age group of 30 &ndash; 60 yrs both male and female and 50 controls of normal healthy persons<span style="mso-bidi-font-weight:&#10;bold"> same<span style="mso-spacerun:yes">&nbsp; </span>age<span style="mso-spacerun:yes">&nbsp; </span>and<span style="mso-spacerun:yes">&nbsp; </span>sex,<span style="mso-spacerun:yes">&nbsp; </span>from<span style="mso-spacerun:yes">&nbsp; </span>general<span style="mso-spacerun:yes">&nbsp; </span>population.</span></span><span style="font-size:14.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"><o:p></o:p></span></p> <p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;text-align:&#10;justify;line-height:normal"><b><span style="font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">Results &amp; Observations: </span></b><span style="font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">The values of T3 and T4 were significantly lower in cases as compared to controls while TSH values were significantly high in cases as compared to control. Calcium and Vitamin D levels were also significantly low in cases. <o:p></o:p></span></p> <p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;text-align:&#10;justify;line-height:normal"><b><span style="font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">Conclusions:</span></b><span style="font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"> Severity of vitamin D deficiency corresponds to the severity of thyroid disease, with progressive increase in TSH level from subclinical to overt hypothyroidism. Thus it may be suggested that vitamin D be supplemented to all hypothyroid patients including the subclinical cases.<o:p></o:p></span></p>

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Cite This Article:

Yogita Dubey, Archana Dhok, Ruchir Khare, STATUS OF SERUM CALCIUM AND VITAMIN-D LEVEL IN HYPOTHYROIDISM IN ONE OF THE RURAL AREA OF CENTRAL MAHARASHTRA, GLOBAL JOURNAL FOR RESEARCH ANALYSIS : Volume-7 | Issue-8 | August-2018


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