Volume : 7, Issue : 8, August - 2018

COGNITIVE FUNCTION ASSESSMENT IN MILD TO MODERATE COPD PATIENTS THROUGH P300, ERP STUDY.

Namita, Rajiv Bandhu, Sujata Gautam, Debasish Chaudhury, Sunita Mondal, Madhulika Monga

Abstract :

<p class="MsoNormal" style="margin-top:6.0pt;margin-right:0in;margin-bottom:12.0pt;&#10;margin-left:0in;text-align:justify;text-justify:inter-ideograph;line-height:&#10;200%"><span style="font-size:12.0pt;line-height:200%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;color:black">Event-related potentials (ERPs) provide a non-invasive method of studying ain neural activity, with P300 wave components reflecting the speed of cognitive processes.<span style="background:white"> In our study we primarily focused on finding cognitive impairment in the initial stage of the Chronic obstructive pulmonary disease</span></span><span style="font-size:12.0pt;&#10;line-height:200%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;color:black;background:&#10;white;mso-ansi-language:EN-US"> </span><span style="font-size:12.0pt;&#10;line-height:200%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;color:black;background:&#10;white">(COPD)</span><span style="font-size:12.0pt;line-height:200%;font-family:&#10;&quot;Times New Roman&quot;,&quot;serif&quot;;color:black"> through latency and amplitude study of P300 wave. <span style="background:white">We enrolled equal number (n</span></span><span style="font-size:12.0pt;line-height:200%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;color:black;background:white;mso-ansi-language:EN-US"> </span><span style="font-size:12.0pt;line-height:200%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;color:black;background:white">=</span><span style="font-size:12.0pt;line-height:&#10;200%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;color:black;background:white;&#10;mso-ansi-language:EN-US"> </span><span style="font-size:12.0pt;line-height:&#10;200%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;color:black;background:white">35) of COPD cases and healthy controls. </span><span style="font-size:12.0pt;&#10;line-height:200%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;color:black">Mean value of Latency at Fz, Cz, Pz was significantly de</span><span style="font-size:&#10;12.0pt;line-height:200%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;color:black;&#10;mso-ansi-language:EN-US">creased</span><span style="font-size:12.0pt;&#10;line-height:200%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;color:black"> in cases as compared to control group (p</span><span style="font-size:12.0pt;line-height:&#10;200%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;color:black;mso-ansi-language:EN-US"> </span><span style="font-size:12.0pt;line-height:200%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;color:black">=</span><span style="font-size:12.0pt;line-height:200%;font-family:&#10;&quot;Times New Roman&quot;,&quot;serif&quot;;color:black;mso-ansi-language:EN-US"> </span><span style="font-size:12.0pt;line-height:200%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;color:black">0.007, p = 0.001, p</span><span style="font-size:12.0pt;&#10;line-height:200%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;color:black;mso-ansi-language:&#10;EN-US"> </span><span style="font-size:12.0pt;line-height:200%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;color:black">=</span><span style="font-size:12.0pt;line-height:200%;font-family:&#10;&quot;Times New Roman&quot;,&quot;serif&quot;;color:black;mso-ansi-language:EN-US"> </span><span style="font-size:12.0pt;line-height:200%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;color:black">0.006 respectively). Similarly, mean averaged latency was also de</span><span style="font-size:12.0pt;line-height:200%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;color:black;mso-ansi-language:EN-US">creased</span><span style="font-size:12.0pt;&#10;line-height:200%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;color:black"> in COPD vs controls (p = 0.00</span><span style="font-size:12.0pt;line-height:200%;&#10;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;color:black;mso-ansi-language:EN-US">8</span><span style="font-size:12.0pt;line-height:200%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;color:black">). Furthermore, </span><span style="font-size:12.0pt;line-height:&#10;200%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;color:black;mso-ansi-language:EN-US">a </span><span style="font-size:12.0pt;line-height:200%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;color:black">significant </span><span style="font-size:12.0pt;line-height:200%;&#10;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;color:black;mso-ansi-language:EN-US">positive </span><span style="font-size:12.0pt;line-height:200%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;color:black">correlation between MEF_25-75%and amplitude at Cz in the COPD cases (r</span><span style="font-size:12.0pt;line-height:200%;&#10;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;color:black;mso-ansi-language:EN-US"> </span><span style="font-size:12.0pt;line-height:200%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;color:black">=</span><span style="font-size:12.0pt;line-height:200%;font-family:&#10;&quot;Times New Roman&quot;,&quot;serif&quot;;color:black;mso-ansi-language:EN-US"> </span><span style="font-size:12.0pt;line-height:200%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;color:black">0.3534,</span><span style="font-size:12.0pt;line-height:200%;&#10;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;color:black;mso-ansi-language:EN-US"> </span><span style="font-size:12.0pt;line-height:200%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;color:black">p</span><span style="font-size:12.0pt;line-height:200%;font-family:&#10;&quot;Times New Roman&quot;,&quot;serif&quot;;color:black;mso-ansi-language:EN-US"> </span><span style="font-size:12.0pt;line-height:200%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;color:black">=</span><span style="font-size:12.0pt;line-height:200%;font-family:&#10;&quot;Times New Roman&quot;,&quot;serif&quot;;color:black;mso-ansi-language:EN-US"> </span><span style="font-size:12.0pt;line-height:200%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;color:black">0.037)</span><span style="font-size:12.0pt;line-height:200%;&#10;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;color:black;mso-ansi-language:EN-US"> </span><span style="font-size:12.0pt;line-height:200%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;color:black">was </span><span style="font-size:12.0pt;line-height:200%;&#10;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;color:black;mso-ansi-language:EN-US">observed</span><span style="font-size:12.0pt;line-height:200%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;color:black">. </span><span style="font-size:12.0pt;line-height:200%;&#10;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;color:black;mso-ansi-language:EN-US">The results obtained in our study suggests that the c</span><span style="font-size:&#10;12.0pt;line-height:200%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;color:black">ognitive dysfunction is present</span><span style="font-size:12.0pt;line-height:200%;&#10;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;color:black;mso-ansi-language:EN-US"> even in mild to moderate</span><span style="font-size:12.0pt;line-height:200%;&#10;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;color:black"> COPD</span><span style="font-size:12.0pt;line-height:200%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;color:black;mso-ansi-language:EN-US"> </span><span style="font-size:12.0pt;&#10;line-height:200%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;color:black">patients</span><span style="font-size:12.0pt;line-height:200%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;color:black;mso-ansi-language:EN-US">. The </span><span style="font-size:12.0pt;&#10;line-height:200%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;color:black">positive </span><span style="font-size:12.0pt;line-height:200%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;color:black;mso-ansi-language:EN-US">association </span><span style="font-size:&#10;12.0pt;line-height:200%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;color:black">between </span><span style="font-size:12.0pt;line-height:200%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;color:black;mso-ansi-language:EN-US">the</span><span style="font-size:12.0pt;&#10;line-height:200%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;color:black"> spirometric parameters and </span><span style="font-size:12.0pt;line-height:&#10;200%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;color:black;mso-ansi-language:EN-US">P300 variables obtained in our study also suggests that with deterioration in lung functions there is decline in cognition</span><span style="font-size:12.0pt;&#10;line-height:200%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;color:black">. </span><span style="font-size:12.0pt;line-height:200%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;color:black;mso-ansi-language:EN-US"><o:p></o:p></span></p>