Volume : 7, Issue : 6, June - 2018

PSORIASIS AND THYROID: A RETROSPECTIVE RESEARCH FROM TURKEY

Dr. Atil Avci, Dr. Deniz Avci

Abstract :

<p class="MsoNormal" style="line-height:150%"><span style="font-size:12.0pt;&#10;line-height:150%;mso-bidi-font-family:Calii;mso-bidi-theme-font:minor-latin;&#10;mso-ansi-language:EN-US">AİM<o:p></o:p></span></p> <p class="MsoNormal" style="line-height:150%"><span style="font-size:12.0pt;&#10;line-height:150%;mso-bidi-font-family:Calii;mso-bidi-theme-font:minor-latin;&#10;mso-ansi-language:EN-US">Psoriasis is a chronic, inflammatory and immuno-mediated skin disease. Many autoimmune diseases have been reported with psoriasis such as autoimmune thyroiditis. Although the relationship between psoriasis and thyroid has been repeatedly studied and over-emphasized, this relationship has not yet been fully elucidated. <o:p></o:p></span></p> <p class="MsoNormal" style="line-height:150%"><span style="font-size:12.0pt;&#10;line-height:150%;mso-bidi-font-family:Calii;mso-bidi-theme-font:minor-latin;&#10;mso-ansi-language:EN-US">PATIENTS AND METHOD<o:p></o:p></span></p> <p class="MsoNormal" style="line-height:150%"><span style="font-size:12.0pt;&#10;line-height:150%;mso-bidi-font-family:Calii;mso-bidi-theme-font:minor-latin;&#10;mso-ansi-language:EN-US">The study was carried out with a retrospective review of the files of psoriasis patients (n=82) and healty controls (n=47) admitted to the Dermatology clinics. Age, gender, serum anti-TPO levels, anti-TG levels, thyroid stimulating hormone (TSH) levels, free T3 levels and free t4 levels were corresponden between the two groups. <o:p></o:p></span></p> <p class="MsoNormal" style="line-height:150%"><span style="font-size:12.0pt;&#10;line-height:150%;mso-bidi-font-family:Calii;mso-bidi-theme-font:minor-latin;&#10;mso-ansi-language:EN-US">RESULTS<o:p></o:p></span></p> <p class="MsoNormal" style="line-height:150%"><span style="font-size:12.0pt;&#10;line-height:150%;mso-bidi-font-family:Calii;mso-bidi-theme-font:minor-latin;&#10;mso-ansi-language:EN-US">The median anti-TPO level of psoriatic patients was 5.6 (0.1-1300) IU/L. In the control group, the median anti TPO level was 1.30 (0.2-727.6) IU/L. The difference was statistically significant (p &lt;0.001).<o:p></o:p></span></p> <p class="MsoNormal" style="line-height:150%"><span style="font-size:12.0pt;&#10;line-height:150%;mso-bidi-font-family:Calii;mso-bidi-theme-font:minor-latin;&#10;mso-ansi-language:EN-US">The median anti-TG level of psoriatic patients was 3.65 (0.1-310) IU/L. The median anti-TG level of healthy controls was 2.20 (2.20-511.2) IU/L. The difference was statistically significant (p=0.001).<o:p></o:p></span></p> <p class="MsoNormal" style="line-height:150%"><span style="font-size:12.0pt;&#10;line-height:150%;mso-bidi-font-family:Calii;mso-bidi-theme-font:minor-latin;&#10;mso-ansi-language:EN-US">The mean free T3 level of patients with psoriasis was 2.56 (0.63-4.52) IU/L. In healthy controls this level was 3.11 (1.70-4.44) IU/L. There was a statistically significant difference (p=0.002).<o:p></o:p></span></p> <p class="MsoNormal" style="line-height:150%"><span lang="TR" style="font-size:&#10;12.0pt;line-height:150%;mso-bidi-font-family:Calii;mso-bidi-theme-font:minor-latin">CONCLUSION<o:p></o:p></span></p> <p class="MsoNormal" style="line-height:150%"><span style="font-size:12.0pt;&#10;line-height:150%;mso-bidi-font-family:Calii;mso-bidi-theme-font:minor-latin;&#10;mso-ansi-language:EN-US">In our view, the relationship between these two diseases can be better elucidated by extensive studies on pathogenesis.<o:p></o:p></span></p>