Volume : 7, Issue : 2, February - 2018

Comparative study of two combinations of ropivacaine and fentanyl for postoperative pain relief after umblical and lower abdominal surgeries

Dr. Nidhi Asati, Dr Amit Jain, Dr Nitish Nayak, Dr K K Arora

Abstract :

<p>&nbsp;</p> <p class="MsoNormal" style="margin-bottom:7.5pt;text-align:justify;text-justify:&#10;inter-ideograph;background:white"><b><span style="font-size:12.0pt;line-height:&#10;115%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;mso-fareast-font-family:&quot;Times New Roman&quot;">Objectives</span></b><span style="font-size:12.0pt;line-height:115%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;mso-fareast-font-family:&quot;Times New Roman&quot;;mso-bidi-font-weight:bold">:&nbsp;Ropivacaine</span><span style="font-size:12.0pt;line-height:115%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;mso-fareast-font-family:&quot;Times New Roman&quot;"> has been used, either alone or with local anesthetics, for <span style="mso-spacerun:yes">&nbsp;</span>epidural analgesia. This study was undertaken to compare quality and safety of two combinations of epidural ropivacaine with fentanyl<span style="mso-spacerun:yes">&nbsp; </span>for providing postoperative analgesia for 48 hours after <span style="mso-font-kerning:18.0pt;mso-bidi-font-weight:bold">umblical and lower abdominal surgeries</span> .<o:p></o:p></span></p> <p class="MsoNormal" style="margin-bottom:7.5pt;text-align:justify;text-justify:&#10;inter-ideograph;background:white"><b><span style="font-size:12.0pt;line-height:&#10;115%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;mso-fareast-font-family:&quot;Times New Roman&quot;">Methodology:&nbsp;</span></b><span style="font-size:12.0pt;line-height:115%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;mso-fareast-font-family:&quot;Times New Roman&quot;">In a prospective randomized, controlled study, 70 patients age group between 20-60 years, of either gender, scheduled for routine <span style="mso-font-kerning:18.0pt;mso-bidi-font-weight:&#10;bold">umblical and lower abdominal surgeries</span> were randomly distributed into two groups of 35 patients each. Postoperatively,<b><span style="mso-font-kerning:&#10;18.0pt"> </span></b><span style="mso-font-kerning:18.0pt;mso-bidi-font-weight:&#10;bold">two combinations of ropivacaine and fentanyl[group 1 ropivacaine .2% and fentanyl 4</span> &micro;g<span style="mso-font-kerning:18.0pt;mso-bidi-font-weight:&#10;bold"> and group 2 ropivacaine .1% and fentanyl 2</span> &micro;g<span style="mso-font-kerning:18.0pt;mso-bidi-font-weight:bold"> ] <span style="mso-spacerun:yes">&nbsp;</span>for postoperative pain relief</span>, diluted in 10 ml of normal saline was injected in the <span style="mso-spacerun:yes">&nbsp;</span>epidural space (between L<sub>2 </sub>&ndash;L<sub>3 </sub>space) through the catheter and then repeated 6 hourly. Pain intensity score, onset of analgesia,number of top-ups required andoverall patient satisfaction score were recorded.<o:p></o:p></span></p> <p class="MsoNormal" style="margin-bottom:7.5pt;text-align:justify;text-justify:&#10;inter-ideograph;background:white"><b><span style="font-size:12.0pt;line-height:&#10;115%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;mso-fareast-font-family:&quot;Times New Roman&quot;">Results:</span></b><span style="font-size:12.0pt;line-height:115%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;mso-fareast-font-family:&quot;Times New Roman&quot;">&nbsp;Mean onset of analgesia was 10.31 &plusmn; 1.5 min with <span style="mso-spacerun:yes">&nbsp;</span>group 1 as against 11.23 &plusmn; 1.2 min with<span style="mso-spacerun:yes">&nbsp; </span>group 2 . Pain Intensity (PPI) score &le; 1 was observed in 68.21% observations belonging to <span style="mso-spacerun:yes">&nbsp;</span>group 1 and in 60 % observations belonging to <span style="mso-spacerun:yes">&nbsp;</span>group 2. Twenty five patients (71.4%) from<span style="mso-spacerun:yes">&nbsp; </span>group 1 and 30 patients (85.7%) from f group 2 required rescue analgesia. The patient&rsquo;s feedback on pain relief was graded as very good or good by 78.5% of the patients in Group-1 and 69% patients in Group-2.<o:p></o:p></span></p> <p class="MsoNormal" style="margin-bottom:7.5pt;text-align:justify;text-justify:&#10;inter-ideograph;background:white"><b><span style="font-size:12.0pt;line-height:&#10;115%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;mso-fareast-font-family:&quot;Times New Roman&quot;">Conclusion:&nbsp;</span></b><span style="font-size:12.0pt;line-height:115%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;mso-fareast-font-family:&quot;Times New Roman&quot;">Though both drug combinations <span style="mso-spacerun:yes">&nbsp;</span>are equally safe,<b>&nbsp;group 1 concentration</b> is faster acting, more potent and efficient analgesic than group 2 when used for postoperative pain relief in <span style="mso-font-kerning:&#10;18.0pt;mso-bidi-font-weight:bold">umblical and lower abdominal surgeries</span>.Howevermotor power was better preserved in group 2<o:p></o:p></span></p>

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Cite This Article:

Dr. Nidhi Asati, Dr Amit Jain, Dr Nitish Nayak, Dr K K Arora, Comparative study of two combinations of ropivacaine and fentanyl for postoperative pain relief after umblical and lower abdominal surgeries, GLOBAL JOURNAL FOR RESEARCH ANALYSIS : VOLUME-7, ISSUE-2, FEBRUARY-2018


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