Volume : 7, Issue : 2, February - 2018

Renal and liver profile in pre and post menopause women attending OPD of a tertiary health care level institute of Haryana, India.

Dr. R. Tiwari, Indra Prasad Adhikari

Abstract :

BACKGROUND: Menopause is a natural step in the process of ageing in a woman‘s life, when her menstruation stops and she is no longer fertile due to depletion of ovarian follicles. Onset of menopause alters the liver functions the most common tests include testing for ALT,AST, Bilirubin and Albumin. Similarly renal function status also alters in terms of urea, creatinine and calcium. Chronic kidney disease (CKD) in women is often accompanied by menstrual and fertility disorders as a consequence of kidney-mediated endocrine disturbances. METHODOLOGY: 50 healthy premenopausal & 50 healthy  postmenopausal women were included in study, 5 ml. of venous blood was taken in red vaccutainer and serum was separated. Liver profile and renal profile was estimated by enzymatic method in auto analyser. RESULTS: in the present study the mean values of kidney profile in premenopausal group was  found as (in mg/dl) urea (22.22  ± 5.07)<span style="font-size:13.0pt;
line-height:150%;font-family:"Times New Roman","serif";mso-fareast-font-family:
"Times New Roman";mso-ansi-language:EN-US;mso-fareast-language:EN-US;
mso-bidi-font-weight:bold">, creatinine,( 0.69 ± 0.13) calcium,( 9.73 ± 0.60) , phosphorus(3.06 ± 0.42) and  in postmenopausal group  was found as  urea( 25.94 ± 4.386) , creatinine ( 0.740 ± 0.136), calcium (9.89 ± 0.598), phosphorus( 3.20 ± 0.49)<span lang="EN-IN" style="font-size:13.0pt;line-height:150%;font-family:"Times New Roman","serif";
mso-fareast-font-family:"Times New Roman";mso-ansi-language:EN-US;mso-fareast-language:
EN-US;mso-bidi-font-weight:bold"> . The p values for this were found as for  urea (p= <0.05), for creatinine ( p = 0.115), calcium ( p= 0.185) & for  phosphorus(p=0.145) . In present study liver parameters in premenopausal group of women  found as (U/L, mean ± SD) of  SGOT was (24.40 ± 4.58) <span style="font-size:13.0pt;line-height:150%;
font-family:"Times New Roman","serif";mso-fareast-font-family:"Times New Roman";
color:black;letter-spacing:-.15pt;mso-ansi-language:EN-US;mso-fareast-language:
EN-US"> and for SGPT it was found (27.06 ± 6.61) & for <span style="font-size:13.0pt;line-height:150%;
font-family:"Times New Roman","serif";mso-fareast-font-family:"Times New Roman";
color:black;letter-spacing:-.15pt;mso-ansi-language:EN-US;mso-fareast-language:
EN-US"> ALP was found (74.56 ± 20.80) and in postmenopausal group these  values were found as   (28.78 ± 5.39),(31.14 ± 4.42) & (86.16 ± 18.17) respectively.CONCLUSION: This study suggests that there is increase in liver and kidney profile parameters   in postmenopausal women as compared to premenopausal women i.e. postmenopausal women have more risk of liver and kidney damage hence a timely health check up must be intensified specially among postmenopausal women.<o:p></o:p>

Keywords :

ALT AST pre and post Menopausal women.

Article:

Download PDF Journal DOI : 10.15373/2249555X

Cite This Article:

Dr. R. Tiwari, Indra Prasad Adhikari, Renal and liver profile in pre and post menopause women attending OPD of a tertiary health care level institute of Haryana, India., GLOBAL JOURNAL FOR RESEARCH ANALYSIS : VOLUME-7, ISSUE-2, FEBRUARY-2018