Volume : 7, Issue : 1, January - 2018

A correlation between Serum Adiponectin level and Type 2 Diabetes: A Meta- Analysis of 5403 subjects

Akanksha Dubey, Dr P. J. Hisalkar

Abstract :

<p>&nbsp;</p> <p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;mso-layout-grid-align:&#10;none;text-autospace:none"><span lang="EN-IN" style="font-size:12.0pt;line-height:&#10;115%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">The increasing prevalence of Type 2 Diabetes has become a major public health challenge throughout the world, with 366 million prevalent diabetic cases in 2011 and a projected 552 million cases expected by the year 2030^[1]. Both lifestyle factors, including diet and physical activity, and genetic factors contribute to the accelerating diabetes epidemic^[2]. </span><span lang="EN-IN" style="font-size:&#10;12.0pt;line-height:115%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;mso-fareast-font-family:&#10;&quot;Times New Roman&quot;">The<span style="letter-spacing:.6pt"> </span>designation of<span style="letter-spacing:.15pt"> </span>the<span style="letter-spacing:.55pt"> </span>adipose<span style="letter-spacing:1.4pt"> </span>tissue<span style="letter-spacing:.4pt"> </span>as<span style="letter-spacing:.15pt"> </span>a<span style="letter-spacing:.25pt"> </span>pivotal<span style="letter-spacing:1.2pt"> </span>active<span style="letter-spacing:.45pt"> </span><span style="mso-font-width:106%">endo</span>crine<span style="letter-spacing:2.0pt"> </span>organ <span style="letter-spacing:.8pt">has</span> indeed <span style="letter-spacing:.1pt">drawn</span> <span style="letter-spacing:.8pt">much </span>scientific<span style="letter-spacing:1.8pt"> </span>interest<span style="letter-spacing:.8pt"> </span>in<span style="letter-spacing:1.75pt"> </span><span style="mso-font-width:107%">the </span>last<span style="letter-spacing:1.0pt"> </span>few years.<span style="letter-spacing:1.15pt"> </span>The<span style="letter-spacing:&#10;1.15pt"> </span>adipose<span style="letter-spacing:1.9pt"> </span>tissue<span style="letter-spacing:.95pt"> </span>is<span style="letter-spacing:.1pt"> </span>now<span style="letter-spacing:1.1pt"> </span>viewed<span style="letter-spacing:.3pt"> </span>as<span style="letter-spacing:.7pt"> </span>the<span style="letter-spacing:1.1pt"> </span><span style="mso-font-width:105%">largest </span>endocrine <span style="letter-spacing:&#10;1.8pt">organ</span> <span style="letter-spacing:1.65pt">in</span> <span style="letter-spacing:.3pt">the</span> <span style="letter-spacing:.8pt">body</span> ^[3]</span><span lang="EN-IN" style="font-size:12.0pt;line-height:115%;&#10;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"> </span><span lang="EN-IN" style="font-size:12.0pt;line-height:115%;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;&#10;mso-fareast-font-family:&quot;Times New Roman&quot;;color:black">It <span style="mso-font-width:102%">secretes </span>numerous<span style="mso-spacerun:yes">&nbsp;&nbsp; </span>bioactive <span style="letter-spacing:1.15pt">proteins</span>, <span style="letter-spacing:1.95pt">collectively</span><span style="letter-spacing:&#10;2.05pt"> </span>known <span style="letter-spacing:1.5pt">adipocytes</span><span style="mso-font-width:105%">, </span>into <span style="letter-spacing:.05pt">the</span><span style="letter-spacing:1.75pt"> </span>circulation. ^[4] The<span style="letter-spacing:1.8pt"> </span>most<span style="mso-spacerun:yes">&nbsp; </span><span style="mso-font-width:108%">abun</span>dant<span style="mso-spacerun:yes">&nbsp;&nbsp; </span>of <span style="letter-spacing:.7pt"><span style="mso-spacerun:yes">&nbsp;</span></span>these <span style="letter-spacing:1.15pt"><span style="mso-spacerun:yes">&nbsp;</span></span><span style="mso-font-width:106%">adipo-cytokines <span style="letter-spacing:.1pt"><span style="mso-spacerun:yes">&nbsp;</span></span></span>is <span style="letter-spacing:.2pt"><span style="mso-spacerun:yes">&nbsp;</span></span>the <span style="letter-spacing:1.1pt"><span style="mso-spacerun:yes">&nbsp;</span></span><span style="mso-font-width:107%">adiponectin <span style="letter-spacing:.15pt"><span style="mso-spacerun:yes">&nbsp;</span></span></span>which <span style="letter-spacing:&#10;1.1pt"><span style="mso-spacerun:yes">&nbsp;</span></span>is secreted <span style="letter-spacing:.3pt"><span style="mso-spacerun:yes">&nbsp;</span></span>by<span style="letter-spacing:2.0pt"> </span>white<span style="mso-spacerun:yes">&nbsp; </span>adipose <span style="letter-spacing:1.05pt"><span style="mso-spacerun:yes">&nbsp;</span></span>tissue<span style="mso-spacerun:yes">&nbsp; </span>and <span style="letter-spacing:.7pt"><span style="mso-spacerun:yes">&nbsp;</span></span>accounts <span style="letter-spacing:&#10;1.35pt"><span style="mso-spacerun:yes">&nbsp;</span></span>for <span style="letter-spacing:.25pt"><span style="mso-spacerun:yes">&nbsp;</span></span>0.01% <span style="letter-spacing:.75pt"><span style="mso-spacerun:yes">&nbsp;</span></span><span style="mso-font-width:105%">of </span>total<span style="mso-spacerun:yes">&nbsp; </span><span style="letter-spacing:1.9pt"><span style="mso-spacerun:yes">&nbsp;</span></span>plasma<span style="mso-spacerun:yes">&nbsp; </span><span style="letter-spacing:1.65pt"><span style="mso-spacerun:yes">&nbsp;</span></span>proteins. ^{[5, 6]<o:p></o:p>}</span></p>