Volume : 7, Issue : 1, January - 2018

Clinical study of the lower esophageal sphincter electrical stimulation

Sergiu Ungureanu, Natalia Sipitco, Vladimir Vidiborschii, Doina Fosa

Abstract :

<p>&nbsp;</p> <p class="MsoNormal" style="text-align:justify;text-justify:inter-ideograph;&#10;text-indent:0in;line-height:200%"><b style="mso-bidi-font-weight:normal"><span style="font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;mso-ansi-language:EN-US">BACKGROUND:</span></b><span style="font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;mso-ansi-language:EN-US"> Recently the possibility of LES tonus increasing by the means of implantable electrical stimulator was described. Although this method is already used in clinical practice, optimal parameters of LES electrical stimulation are still unknown. <o:p></o:p></span></p> <p class="MsoNormal" style="text-align:justify;text-justify:inter-ideograph;&#10;text-indent:0in;line-height:200%"><b style="mso-bidi-font-weight:normal"><span style="font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;mso-ansi-language:EN-US">AIMS:</span></b><span style="font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;mso-ansi-language:EN-US"> The goal of this study was obtaining of clinical data regarding effects of different types of electrical stimulation on LES tonus.<o:p></o:p></span></p> <p class="MsoNormal" style="text-align:justify;text-justify:inter-ideograph;&#10;text-indent:0in;line-height:200%"><b style="mso-bidi-font-weight:normal"><span style="font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;mso-ansi-language:EN-US">METHODS:</span></b><span style="font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;mso-ansi-language:EN-US"> LES electrical stimulation was assessed in 15 patients with GERD. These patients underwent standard laparoscopic antireflux surgery with additional insertion of 2 temporary electrodes at the level of gastroesophageal junction. Three sets of parameters were studied with high resolution esophageal manometry to assess changes in LES tonus.<o:p></o:p></span></p> <p class="MsoNormal" style="text-align:justify;text-justify:inter-ideograph;&#10;text-indent:0in;line-height:200%"><b style="mso-bidi-font-weight:normal"><span style="font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;mso-ansi-language:EN-US">RESULTS:</span></b><span style="font-family:&quot;Times New Roman&quot;,&quot;serif&quot;;mso-ansi-language:EN-US"> Values of LES resting pressure and integrated relaxation pressure (IRP) were significantly different between prestimulation and poststimulation periods. <b style="mso-bidi-font-weight:normal">CONCLUSIONS:</b> Modifications of LES function during the stimulation and after the stimulation period depend on frequency and pulse width. <o:p></o:p></span></p>