Volume : 6, Issue : 12, December - 2017

Study to assess the impact of Metabolic syndrome on the occurrence of diabetic retinopathy amongst people with types 2 diabetes mellitus in India.

Mrs Kavita Sunil Gupta, Dr Sunil Surajprasad Gupta, Dr Sabiha A. Vali, Dr Ajay Ambade, Dr Sachin B. Gathe

Abstract :

<p>&nbsp;<b style="text-align: justify;"><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">Background:</span></b><span style="text-align: justify; font-size: 12pt; font-family: &quot;Times New Roman&quot;, serif;">People with Type 2DM have high prevalence of metabolic syndrome (MetS). Diabetic retinopathy (DR) is an important cause of morbidity, but its association with MetS is not evaluated in Indian population.</span></p> <p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;text-align:&#10;justify;text-justify:inter-ideograph;line-height:normal"><b><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">&nbsp;</span></b></p> <p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;text-align:&#10;justify;text-justify:inter-ideograph;line-height:normal"><b><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">Objectives: </span></b><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">We aim to assess the prevalence of DR and MetS and also to evaluate the impact of MetS on the occurrence of DR in T2DM.&nbsp; <o:p></o:p></span></p> <p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;text-align:&#10;justify;text-justify:inter-ideograph;line-height:normal;mso-pagination:none;&#10;mso-layout-grid-align:none;text-autospace:none"><b><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">&nbsp;</span></b></p> <p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;text-align:&#10;justify;text-justify:inter-ideograph;line-height:normal;mso-pagination:none;&#10;mso-layout-grid-align:none;text-autospace:none"><b><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">Methods:</span></b><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">Data of 1037 subjects with T2DM on demographics, anthropometry, blood pressure, lipids, CVD and DR was obtained. MetS was defined by NCEP&shy;ATP&shy;III guidelines.Association of DR was evaluated with other variables including MetS and it&rsquo;s components. Statistical analysis was done.<b><o:p></o:p></b></span></p> <p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;text-align:&#10;justify;text-justify:inter-ideograph;line-height:normal"><b><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">&nbsp;</span></b></p> <p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;text-align:&#10;justify;text-justify:inter-ideograph;line-height:normal"><b><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">Results</span></b><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">: </span><span style="font-size: 12pt; font-family: &quot;Times New Roman&quot;, serif;">MetS prevalence was 86.98 % (female-91.3%, male-84.5%), DR was 8.2 % and CVD was 13.5%.</span><span style="font-size:12.0pt;&#10;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"> Waist circumference contributed the most to MetS(91.69%) followed by HDL-C(71.73%) and TG(63.08%).Age and duration of diabetes showed positive association with DR. OR for people with MetS to develop DR was high in univariate and multivariate analysis, though statistically insignificant. T2DM with High Triglyceride </span><span style="font-size: 12pt; font-family: &quot;Times New Roman&quot;, serif;">are at higher risk of DR with OR </span><span style="font-size: 12pt; font-family: &quot;Times New Roman&quot;, serif;">2.0943 [1.2044,3.6415] </span><span style="font-size: 12pt; font-family: &quot;Times New Roman&quot;, serif;">(p-</span><span style="font-size: 12pt; font-family: &quot;Times New Roman&quot;, serif;">0.0088). </span><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"><o:p></o:p></span></p> <p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;text-align:&#10;justify;text-justify:inter-ideograph;line-height:normal;mso-pagination:none;&#10;mso-layout-grid-align:none;text-autospace:none"><b><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">&nbsp;</span></b></p> <p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;text-align:&#10;justify;text-justify:inter-ideograph;line-height:normal;mso-pagination:none;&#10;mso-layout-grid-align:none;text-autospace:none"><b><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">Conclusion: </span></b><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">Prevalence of MetS in Indian T2DM people is high. MetS increases, though insignificantly, while high Triglycerides increase the risk of DR significantly.<o:p></o:p></span></p> <p class="MsoNormal" style="margin-bottom:0in;margin-bottom:.0001pt;text-align:&#10;justify;text-justify:inter-ideograph;line-height:normal"><b><span style="font-size:12.0pt;font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">&nbsp;</span></b></p>