Volume : 8, Issue : 3, March - 2019

STUDY OF ACUTE AND SUB ACUTE TOXICITY OF PALA INDIGO (WRIGHTIA TINCTORIA) IN ANIMAL MODELS

Dr. M. Naiyna Mohamed

Abstract :

Introduction: W.tinctoria often referred to as Snowflake Tree or Pala Indigo used as a vermifuge, antidiarrhoeal, antihaemorrhagic and a hepatoprotective agent. The present study has been designed to get better understanding about the actions of Wrightia tinctoria leaves on acute and sub acute toxicity studies. Materials and methods: Acute toxicity was evaluated in Wistar albino rats by oral administration of single dose of aqueous extract, crude powder and alcohol extract of plant Wrightia tinctoria leaves. Sub acute toxicity studies should always attempt to expose the animals by the same route that is likely to be exposed. Results and discussion: Mortality was not observed in the three groups observed up to 72 hrs. Sub-acute toxicity study is indicative of the plant having no toxic effect on liver during repeated administrations as indicated by the absence of any alteration in the values of the biochemical parameters.