Volume : 8, Issue : 3, March - 2019

STUDY ON ASEESSMENT OF CYSTATIN C LEVELS AS EARLY MARKER FOR RENAL IMPAIRMENT IN TYPE 2 DIABETIC SUBJECTS

Dr. Shrikant Chandrakar, Dr. Sushma Bj, Dr. Bharathi Bk

Abstract :

Background: Diabetic Nephropathy is the leading cause of end-stage-renal disease (ESRD) worldwide and is predominantly due to increasing prevalence of type 2 Diabetes Mellitus. It is clinically characterized by decline in glomerular filtration rate (GFR) and increasing rates of urinary albumin excretion starting from normoalbuminuria which progresses to microalbuminuria, macroalbuminuria and eventually to ESRD. Objectives of the study: To estimate and compare serum cystatin levels between controls and type 2 diabetic subjects and to study the diagnostic accuracy of cystatin c in assessing the renal impairment. Materials and Methods: A total number of 90 patients were studied comprising of 30 controls and 60 proven cases of type 2 diabetic patients. Serum concentrations of Cystatin C, Creatinine, Fasting Serum Glucose and Urine Albumin Creatinine Ratio were measured. The statistical analysis was carried out using by Student t-test and Diagnostic Validity Test. Results: The levels of serum cystatin C, creatinine and ACR were found to be significantly increased in diabetic patients compared to controls (p < 0.001). We also found that the diagnostic accuracy of serum cystatin C was found to be better as compared to serum creatinine in assessing early renal impairment in diabetic patients. Conclusion: Our Study suggests that serum cystatin C allows early diagnosis of decline in GFR and is superior to creatinine in assessing renal glomerular function. So, it can be used for early screening and diagnosis of diabetic nephropathy.